In Indigo Prophecy, New York City is stunned by a series of mysterious murders, all following the same pattern: ordinary people are killing absolute strangers in public areas. Lucas Kane becomes another one of these murderers when he suddenly kills a stranger in a men's bathroom. Covered in blood, Lucas regains consciousness with no recollection as to why he committed murder. Hunted by the police, Lucas must uncover the supernatural forces behind his crime before being incarcerated for life.